How Low T Elevates Your Risk of Cardiovascular Disease

By The Vault Team

At Vault, we’re committed to using the latest and best science to optimize men’s health and performance. We know that delivering targeted and effective treatments for every guy begins with research. 

Thankfully, our medical team knows how to innovate. With over 30 years of combined experience specializing in men’s healthcare, our team uses their expertise to incorporate cutting-edge tools to design proven and powerful treatments to support the most common issues men face.

Recently, our Chief Clinical Officer and leading expert on male infertility and sexual dysfunction, Alex Pastuszak, MD, published a study on the relationship between low T levels and cardiovascular disease biomarkers in the Journal of Sexual Medicine.

Here, he discusses what his research found and what it means for the future of men’s health:

Q: Why did you choose to research the relationship between low T and cardiovascular disease?

A: One of the biggest controversies in men’s health is whether or not testosterone actually increases the risk of cardiovascular disease. There is clinical research that has observed an increased risk of cardiovascular disease with low serum testosterone levels and work demonstrated a lower risk of cardiovascular disease in patients with normal testosterone levels.  However, there was also some recent work that showed an increased risk of cardiovascular disease in men who may be taking testosterone, although many sources agreed that these studies used flawed data. Our aim was to use objective biomarker data to better assess the risk of cardiovascular disease in relation to serum testosterone levels.

Q: How was your approach to collecting objective data different?

A: Compared to earlier clinical studies, we partnered with a laboratory that had a large panel of 10 cardiovascular risk biomarkers and a large subset of data of testosterone levels from 10,000+ men. Previous clinical studies only used one or two biomarkers and were limited to much smaller datasets. Our sample was more statistically significant for this study.

Q: What did the results of your study find?

A: Our data showed a direct correlation between increased cardiovascular risk, based on biomarker levels, and low testosterone levels. Our work also suggests that an increased cardiovascular risk may be present when testosterone levels are higher than normal. In a nutshell, our data show that there may be an increased cardiovascular risk in men with both very high and low testosterone levels. Overall, the findings support the conclusion that normalizing testosterone levels may be cardioprotective.

Q: How does this study shape how we think about testosterone and men’s health?

A: Heart disease is the leading cause of death for men in the US. Though there are many ways we think about and treat cardiovascular health, normalizing testosterone levels isn’t usually on the list. Our study suggests that normalizing testosterone levels may be one of the key components of decreasing men’s risk for cardiovascular disease and major adverse cardiovascular events, like heart attacks and stroke.

Want to learn more about how testosterone replacement therapy may improve your heart health?

Book an online appointment with Vault today.

DISCLAIMER: This article is for general information purposes only, does not constitute medical advice and is not intended to be relied upon for medical diagnosis or treatment.  If you are experiencing an emergency, dial 911 or contact a medical provider immediately.  Consistent with Vault Health, Inc.’s website privacy policy, Vault Health, Inc. is not responsible for the privacy practices or the content found at links to other websites.  

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