Low Testosterone’s Impact on Bone Health

By The Vault Team

Bones play an integral role in our health — one that only becomes more important as we age. They store minerals like calcium for the rest of the body to use. They help us thrive from healthy physical activity and avoid injury. They protect our organs and anchor our muscles. 

So, how can you keep bones healthy? Among other factors, testosterone influences bone growth and maintenance. For example, a report in the European Journal of Endocrinology cites a study in which rats receiving testosterone therapy experienced increased bone growth.

In light of this and other research like it, it’s perhaps unsurprising that low testosterone levels can have a negative impact on bone density. Men lose 1.5% of their testosterone per year, starting at age 30. This means that, as testosterone levels drop, bone health does too. Age-related testosterone deficiency is the greatest cause of bone loss in elderly men. 

Bone is living tissue that, when healthy, is regularly broken down and replaced. (This is why we can repair broken bones!) Lowered bone density means that our bones:

  • Can’t replace their matter with as much speed

  • Have reduced mass

  • Have increased fragility

In other words, bones can fracture and break more easily — and mend more slowly and less effectively. While broken bones will still heal, the initial injuries may have lasting repercussions on your body, such as continued pain and reduced mobility.  

The exact way by which testosterone impacts bone health isn’t clear. But it’s presumed that the mechanism involves androgen receptors (AR), found in penal tissue. Testosterone exerts its influence on the body by binding to ARs. The ARs then, through a series of events, impact the up-or-down regulation of genes. 

ARs are also found in osteoblasts, the cells that synthesize bone. As a result, testosterone is presumed to help regulate proliferation, cytokine/growth factor production, and bone matrix production in bone cells through the AR to which it is bound. 

If you’re concerned about bone health, consider looking into your testosterone levels. Doing so is easy and safe. Vault is a modern men’s health company providing men with access to testosterone therapy. We’re here to help you identify and treat low testosterone, so you can get back to living life to its fullest. 

With Vault, you can access clinics with our partner physicians to identify if you have low testosterone. You can also access custom testosterone treatment that’s tailored to your body’s needs. 

This article was reviewed by Aaron Grotas, MD

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