The Powerful Science Behind Testosterone Therapy

By The Vault Team

We’ve written a lot about the prevalence of low T, how levels start to decline after age 30, and how most men don’t connect low testosterone to not feeling on top of their game.

We keep beating this drum because Vault's mission is to help guys perform at their best—and from your brain and heart to your muscles and sexual organs, testosterone affects every single part of your body. Here, we’ve gathered the science behind the profound benefits of testosterone therapy.

Erections, libido, and sexual satisfaction

A set of trials called the Testosterone Trials proved that testosterone therapy improves erections, as well as libido and overall sexual satisfaction. Our own Chief Clinical Officer, Alex Pastuszak, MD, was a co-author on one of the articles about this topic in a peer-reviewed journal, the prestigious Clinical Opinions in Urology.

Cognitive functioning

Normalizing testosterone levels improves blood flow to the brain and has been associated with better performance on tests of memory, executive function, and spatial ability. There are also studies showing a link between normalizing T and a decreased risk of Alzheimer’s. It’s hypothesized that the reason women are at greater risk for Alzheimer’s is because testosterone (when it’s at normal levels) may be preventive.

Life expectancy

What? Taking testosterone can decrease the chance of death? Many studies show that men with lower-than-normal testosterone levels have a higher risk of death from heart attacks—and that treatment with testosterone decreases that risk, thereby decreasing the risk of mortality. 

Obesity and muscle mass

When you have low T and are trying to lose fat or build muscle, it’s like working with both hands tied behind your back. You simply don’t have a great chance of improving your physique if the building blocks aren’t there. Studies bear that out, showing that treating low T helps body composition. 


We know that inflammation is behind many of the diseases of aging—from early cognitive decline to poor immune health to low energy. We also know that optimizing all hormones, including testosterone, keeps inflammation down. This has been clearly proven in clinical studies.


Just as low T contributes to moodiness, depression, and feelings of anxiety, testosterone treatment has been shown to improve overall mood in several trials, including those  mentioned earlier. 

Overall energy

Several studies— among them, one that involved 750 men on testosterone therapy—have shown that T treatment improves overall energy for the entire time the men have stayed on therapy.

That’s a lot of evidence. Yet some men, and even some doctors, say that it’s normal for testosterone levels to decline with age. The argument is that it’s just a natural part of aging. But that’s like saying cataracts are just a natural part of aging. You treat cataracts to improve your vision, and you should treat low T to improve the symptoms and real health risks from abnormally low levels. 

If you are already a Vault member, please call about having your levels tested.  

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